Stabilization of the Spectrin-Like Domains of Nesprin-1α by the...
AbstractNesprins are located at the outer and inner membranes of the nuclear envelope and help link the cytoskeleton to the nucleoskeleton. Nesprin-1α, located at the inner nuclear membrane, binds to...
View ArticleαII Spectrin Stabilizes Stress Fibers and Actin–Membrane Interactions
AbstractThe structure and function of spectrins and spectrin networks have been well-studied in erythrocytes, but the role of spectrins in the cytoskeleton of non-erythroid cells remains unclear....
View ArticleSingle wall carbon nanotubes enter cells by endocytosis and not membrane...
AbstractBackgroundCarbon nanotubes are increasingly being tested for use in cellular applications. Determining the mode of entry is essential to control and regulate specific interactions with cells,...
View ArticleModeling Nuclear Blebs in a Nucleoskeleton of Independent Filament Networks
AbstractCorrelations between altered nuclear shape and disease are empirically observed, but the causes of nuclear dysmorphisms are poorly understood. The nucleoskeleton, which provides the majority of...
View ArticleMechanical Coupling of the Endothelial Cytoskeleton and Nucleus with VEGF...
AbstractVascular endothelial growth factor (VEGF) induces endothelial cell proliferation, migration, and a host of cellular responses that are necessary for angiogenesis. The effects of VEGF on gene...
View ArticleNuclear Stiffening Inhibits Migration of Invasive Melanoma Cells
AbstractDuring metastasis, melanoma cells must be sufficiently deformable to squeeze through extracellular barriers with small pore sizes. We visualize and quantify deformability of single cells using...
View ArticleEarly Passage Dependence of Mesenchymal Stem Cell Mechanics Influences...
Abstract The cellular structures and mechanical properties of human mesenchymal stem cells (hMSCs) vary significantly during culture and with differentiation. Previously, studies to measure mechanics...
View ArticleMechanobiology of Chromatin and the Nuclear Interior
AbstractThe view of the cell nucleus has evolved from an isolated, static organelle to a dynamic structure integrated with other mechanical elements of the cell. Both dynamics and integration appear to...
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